MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrially encoded research peptide supplied by Purity Base as a lyophilized powder. Manufactured to strict laboratory-grade standards and verified by High-Performance Liquid Chromatography (HPLC), it is confirmed at a purity of ≥99%. Its molecular formula is C₂₉₄H₄₅₁N₈₁O₈₃S, with a molecular weight of approximately 2171 Da. The lyophilized presentation ensures structural integrity and batch-to-batch consistency for controlled research applications.

Research background

MOTS-c has been studied extensively in the context of mitochondrial biology and cellular energy regulation. In in vitro models, it has been investigated for its role in:

• Cellular energy metabolism and mitochondrial activity — referenced in studies examining how mitochondrially derived signals modulate metabolic homeostasis.
• Fatty acid oxidation and lipid metabolism — studied as a model compound for understanding the regulation of lipid oxidation pathways at the cellular level.
• Insulin signalling and metabolic function — investigated in research exploring the interaction between mitochondrial peptides and insulin sensitivity in metabolic models.
• Cellular stress response and ageing models — referenced in literature examining adaptive responses to oxidative and metabolic stress.

All findings cited above derive from preclinical and in vitro research contexts. No clinical or therapeutic outcomes are implied.

Reconstitution & handling

MOTS-c is supplied as a lyophilized powder and should be reconstituted with bacteriostatic water (BAC water) prior to use. Add an appropriate volume of BAC water directly to the vial, then gently swirl — do not shake — until the powder is fully dissolved. Avoid vigorous agitation, which may compromise peptide integrity. Once reconstituted, handle the solution with care and keep it cold at all times.

Storage & stability

The lyophilized powder should be stored refrigerated and protected from light and moisture. For long-term preservation, storage at −20 °C is recommended. Once reconstituted, the solution should be kept refrigerated and used within a short timeframe to maintain potency and sterility.

Every order of MOTS-c from Purity Base is accompanied by a batch-specific Certificate of Analysis (CoA), confirming purity and identity as determined by HPLC analysis.