Reta (LY-3437943) is a synthetic research peptide composed of 39 amino acids, supplied as a lyophilized powder with a verified purity of ~99.3% by HPLC. As a triple receptor agonist targeting the GLP-1, GIP, and glucagon receptors, it represents a structurally advanced tool for investigators working at the intersection of metabolic biochemistry and peptide pharmacology. Its molecular formula is C221H342N46O68, with a molecular weight of 4,731.33 Da.

Research background

Reta (LY-3437943) has been investigated in preclinical research contexts for its simultaneous engagement of three distinct incretin and glucagon-related receptor pathways. It has been referenced in the literature as a next-generation advancement beyond dual-agonist peptide frameworks, studied in relation to glucose homeostasis, energy expenditure, lipid metabolism, and appetite signalling. Its triple agonist profile has made it a subject of interest in research models exploring metabolic disorders, obesity, and type 2 diabetes. The concurrent activation of GLP-1, GIP, and glucagon receptors has been studied as a means of examining the synergistic interplay between satiety regulation and fat oxidation pathways.

Reconstitution & handling

Reta is supplied as a lyophilized powder and should be reconstituted with bacteriostatic water (BAC water) prior to use. Add an appropriate volume of BAC water directly to the vial, then gently swirl — do not shake — until the powder is fully dissolved. Avoid vigorous agitation, which may compromise peptide integrity. Handle reconstituted solution with care and keep cold throughout use.

Storage & stability

The lyophilized powder should be stored in a cool, dry location protected from light and moisture; long-term storage at frozen temperatures is recommended to preserve stability. Once reconstituted, the solution should be kept refrigerated and used within a short period. Repeated freeze-thaw cycles of the reconstituted solution should be avoided.

Every order is accompanied by a batch-specific Certificate of Analysis (CoA), including HPLC and mass spectrometry data, verified by Janoshik Independent Peptide Analytics.

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