SS31

SS-31, also known as Elamipretide, is a synthetic tetrapeptide belonging to the Szeto–Schiller (SS) peptide family. Supplied as a lyophilized powder with a purity of ≥98% (HPLC), it is designed for use in controlled laboratory research environments, where its targeted interaction with mitochondrial membranes makes it a well-characterised biochemical tool.

The compound carries the amino acid sequence D-Arg–Dmt–Lys–Phe and is notable for its ability to interact with mitochondria independently of membrane potential — a property that distinguishes it within the SS peptide class and underpins its relevance as a preclinical research model.

Research background

SS-31 (Elamipretide) has been extensively studied in preclinical and in vitro settings focused on mitochondrial biology. Specific areas referenced in the scientific literature include:

• Mitochondrial membrane interaction and structural stabilisation studies.
• Investigations into cellular bioenergetics and energy metabolism pathways.
• Preclinical research models examining oxidative stress and reactive oxygen species modulation.
• Studies exploring mitochondrial function under conditions of cellular stress.

Reconstitution & handling

SS-31 is supplied as a lyophilized powder and should be reconstituted with an appropriate volume of bacteriostatic water (BAC water) prior to use. To dissolve, gently swirl the vial — do not shake, as this may degrade the peptide. All handling should be performed under clean laboratory conditions using appropriate aseptic technique. Once reconstituted, keep the solution refrigerated and avoid repeated freeze-thaw cycles.

Storage & stability

The lyophilized product should be stored cool or frozen and protected from light and moisture. Reconstituted solution should be kept refrigerated and used within a short period. Avoid prolonged exposure to elevated temperatures in either form.

Every order of SS-31 is accompanied by a batch-specific Certificate of Analysis (CoA), confirming identity and purity to ≥98% by HPLC.