Vasoactive Intestinal Peptide (VIP)

Vasoactive Intestinal Peptide (VIP) is a synthetic 28-amino acid peptide supplied as a lyophilized powder of ≥98% purity (HPLC verified). With a molecular formula of C147H237N43O42 and a molecular weight of 3325.74 Da, it is a well-characterised reference compound used across preclinical and in-vitro research disciplines involving neuroendocrine signalling, vascular modulation, and receptor-mediated cellular communication.

Research background

VIP has been extensively studied in the context of neuropeptide signalling, acting via the VIPR1 and VIPR2 receptor subtypes. It has been investigated as a model compound for understanding receptor-mediated signal transduction and cyclic AMP pathway activation. The literature references its use in preclinical settings examining vasodilatory mechanisms, neuro-immunological communication, and the regulation of secretory and smooth-muscle functions. Its defined sequence and high purity make it a reproducible tool for controlled in-vitro receptor-binding and functional assays.

Reconstitution & handling

The lyophilized powder is reconstituted with an appropriate volume of bacteriostatic water (BAC water). Add the BAC water gently to the vial and swirl slowly until the powder is fully dissolved — do not shake, as this may cause peptide degradation. Prepare solutions under aseptic conditions. Once reconstituted, handle the solution with care to preserve stability.

Storage & stability

Store the lyophilized product in a cool, dry location, protected from direct light and moisture. For longer-term storage, keeping the vial frozen is recommended. Once reconstituted, store the solution refrigerated (2–8 °C) and use within a short timeframe to maintain integrity and activity. Avoid repeated freeze-thaw cycles.

Every order of Vasoactive Intestinal Peptide (VIP) is accompanied by a batch-specific Certificate of Analysis (CoA), confirming identity and purity to Purity Base quality standards.